"It's the cost of fighting a debilitating disease and winning." Megadeth frontman Dave Mustaine reveals the damage chemotherapy caused while he was being treated for throat cancer

Dave Mustaine of Megadeth performs onstage during the Tuska Festival at Suvilahti on June 26, 2026 in Helsinki
(Image credit: Venla Shalin/Redferns)

Megadeth frontman Dave Mustaine has revealed the physical toll of receiving a lengthy bout of chemotherapy for stage-three squamous cell carcinoma in his new memoir, In My Darkest Hour.

Mustaine received his throat cancer diagnosis in the summer of 2019, and in an interview with California Post, he says that he struggled while working on material for their 2022 album The Sick, the Dying... and the Dead! due to radiation-related cognitive impairment.

"A lot slipped through the cracks due to a phenomenon known as 'chemo brain'," says Mustaine recalling that period of his life. "Putting all that stuff into your system, the chemotherapy is killing you. The job of the doctors is to take you to the brink of death and bring you back.

"A couple of things that happened because of the radiation and chemotherapy was that fog that I struggled through the first couple years," he adds. "It was really bad. I couldn't remember stuff I would say. We were making The Sick, the Dying... and the Dead! at the same time. So it was particularly hard doing that record; trying to have an idea concept for a song and to develop it when you can't remember what your middle name is.

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"The second thing that happens that has been really awful has been what the radiation did to my teeth. My teeth have been breaking and I'm having to have them replaced. You know, they look good, but it's the cost of of fighting a debilitating disease and winning."

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The Megadeth founder also said it was important for his family and friends to share their perspectives from his period of treatment in the book, so that it may help others in the same situation.

"I wanted to have everybody that was there telling their story because you know, like the guitar tech that I had at the time that was driving me to the appointments," he explains. "I doubt very seriously when he signed up to be my guitar tech, he thought he'd be driving me to life-saving doctor's appointments, but that's what happened.

"I wanted to get everybody's emotional state around the whole thing – not only to help the patient or the reader who has somebody in their life that has been diagnosed. If they're thinking, 'What do I do now?' You do everything you're supposed to and and then some. And then after that, you keep doing everything that you're supposed to."

In My Darkest Hour: A Memoir by Dave Mustaine with Joe Layden, will be released in the UK through Constable on September 24.

The cover art for Dave Mustaine's new memoir

(Image credit: Constable)

Born in 1976 in Newcastle-upon-Tyne, Simon Young has been a music journalist for twenty-seven years. His fanzine, Hit A Guy With Glasses, enjoyed a one-issue run before he secured a job at Kerrang! in 1999. His writing has also appeared in Classic Rock, Metal Hammer, Prog, and Planet Rock. His first book, So Much For The 30 Year Plan: Therapy? — The Authorised Biography was published in 2020 through Jawbone.

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